Yes. All FDA-required studies to support the safety of sucralose during pregnancy and nursing have been performed. As a result, the FDA and other important health authorities have concluded that sucralose is suitable for use by everyone, including pregnant and nursing women. SPLENDA® Brand Sweetener may be used as part of a healthy pre-natal and post-natal diet to help reduce excess calories from added sugars.
No. Extensive research, including randomized, double-blind, placebo-controlled clinical trials in persons with diabetes, shows that sucralose has no effect on blood glucose control.1,2M
The term Acceptable Daily Intake (ADI) is not a threshold for safety. However, regulators set this intake level as a way to help describe safety. It represents a daily intake that, if maintained over a lifetime, is 100 times lower than amounts found to be safe in studies designed to detect potential safety risks. FDA defined an ADI for sucralose of 5 mg/kg body weight. Other important health and regulatory bodies, such as the Joint Expert Committee on Food Additives of the World Health Organization, the European Union's Scientific Committee on Food, and Food Standards Australia/New Zealand have set the ADI for sucralose at 15 mg/kg/day.
Because there are no health risks expected with sucralose use, your patients may consume a variety of products containing SPLENDA® Brand Sweetener (sucralose) to reduce their calorie and carbohydrate intake from sugar without concern that they're exceeding safe intake levels.
SPLENDA® Brand Sweetener (sucralose) is unique among no-calorie sweeteners. It has a clean, sugar-like taste without the bitter aftertaste of some other no-calorie sweeteners, such as saccharin and acesulfame-K.3-5 And unlike aspartame, it holds up to heat, so it can be used in cooking and baking.5 you can substitute SPLENDA® No Calorie Sweetener, Granulated for sugar in your favorite recipes cup for cup.
SPLENDA® Brand Sweetener is found in more than 4,000 products, worldwide, that can help make it easier for your patients to reduce their added sugar intake and plan healthier meals.
Because current dietary guidelines recommend that everyone reduce excess added sugar in their daily diets, SPLENDA® Brand Sweetener is a great way to reduce sugar intake without compromising taste.
Sucralose, the no-calorie sweetening ingredient in SPLENDA® Sweetener Products, is made with an innovative process that starts with sugar (sucrose) and selectively replaces three hydrogen-oxygen groups on the sugar molecule with three chlorine atoms. The result is a sweetener that tastes like sugar and comes in a variety of forms — including SPLENDA® No Calorie Sweetener, Granulated — which does not lose sweetness even with cooking and baking.
Yes. Chlorine is a natural component of table salt, and is naturally present in many foods, such as lettuce, tomatoes, mushrooms, and peanut butter. Chlorine is also part of more complex molecules naturally found in other foods such as lentils, peas, and potatoes. Chlorine is also added to most public drinking water supplies.
Chlorine is used in a process that modifies sucrose to result in the exceptionally stable no-calorie sweetener — sucralose. The chlorine atoms in sucralose prevent it from being broken down in the body for energy, thus rendering it noncaloric.
Extensive research shows that SPLENDA® Brand Sweetener (sucralose) can be used safely by everyone, and there is no cause for concern about safety due to the presence of chlorine.8
No. Migraines can be caused by many things including common events such as stress or changes in vasodilation. Research does not support that sucralose causes migraines or headaches. There are no adverse effects expected with sucralose use. Sucralose is not known to produce changes in the body that are associated with headaches or migraines. For example, sucralose has no known effects on vasodilation (opening of blood vessels) or blood pressure. Studies show no effect on blood glucose or insulin levels, and there are no known effects on the nervous system.
No. SPLENDA® Brand Sweetener (sucralose) does not cause weight gain. Rather, it can help decrease caloric intake when used in place of sugar. The use of no-calorie sweeteners to help decrease caloric intake, along with regular physical activity, may help with weight management.
While it has been suggested by some that no-calorie sweeteners may cause weight gain, such conclusions are frequently based on studies that were not designed to understand its actual effect on weight management. Often, they are studies of very short duration, involving only a small number of animals. This includes, for example, a recent study in male rats funded by the Sugar Association that was subsequently found to have serious design flaws and conclusions that are unreliable and unsupported by the study data. The Expert Panel that investigated this study published their findings in the journal Regulatory Toxicology and Pharmacology,7 and concluded that the results of the study in question cannot be viewed as evidence that either SPLENDA® No Calorie Sweetener or sucralose cause any adverse effects. For more information, go to: News and Latest Research.
By contrast, studies for up to three years in humans support that no-calorie sweeteners can be useful in weight management strategies.9 Additionally, rigorous, large studies in rats that received sucralose at doses equal in sweetness to over 40 pounds of sugar per day over a lifetime showed that sucralose does not cause increases in body weight.6
A 2007 study published in Pediatrics, the official journal of the American Academy of Pediatrics, demonstrated that by making two simple changes daily (using SPLENDA® Brand Sweetener as part of a program to reduce calorie intake and increasing activity levels) families can help overweight children slow their rate of weight gain.8
1. Mezitis NJ, Maggio CA, Koch P, et al. Glycemic effect of a single high oral dose of the novel sweetener sucralose in patients with diabetes. Diabetes Care 1996;19(9):1004-1005.
2. Grotz VI, Henry RR, McGill JB, et al. Lack of effect of sucralose in glucose homeostasis in subjects with type 2 diabetes. J Am Diet Assoc 2003;103:1607-1612.
3. Kuhn C, Bufe B, Winnig M, et al. Bitter taste receptors for saccharin and acesulfame-K. J Neurosci 2004;24(45):10250-10265.
4. Home J, Lawless HT, Speirs W, Sposato D. Bitter taste of saccharin and acesulfame-K. Chem Senses 2002;27:31-38.
5. Nelson AL. Sweeteners: Alternative - Practical Guides for the Food Industry. St. Paul, MN: Eagan Press, 2000.
6. Grotz VL, Munro IC. An overview of the safety of sucralose. Regul Toxicol Pharmacol 2009;55(1):1-5.
7. Brusick D, Borzelleca JF, Gallo M, et al. Expert panel report on a study of SPLENDA® in male rats. Regul Toxicol Pharmacol 2009;55:6-12.
8. Rodearmel SJ, Wyatt HR, Stroebele N, et al. Small changes in dietary sugar and physical activity as an approach to preventing excessive weight gain: the America on the Move family study. Pediatrics 2007:120:e869-e879.
9. De La Hunty A, Gibson S, Ashwell M. A review of the effectiveness of aspartame in helping with weight control. Br Nutr Found Nutr Bull 2006;31:115-128.
SPLENDA® Sugar Blend is a mix of pure sugar (sucrose) and SPLENDA® Brand Sweetener (sucralose). This product, with its great-tasting sweetness, was particularly designed for use in baking, where sugar can be important for certain baked good properties, like moisture and texture. Your patient can make great-tasting, moist, and fluffy baked good that have half the calories typically present from the use of sugar or other full-calorie sweeteners, like honey. In SPLENDA® Sugar Blend, half the sweetness comes from pure sugar and half comes from sucralose, so your patients will only need to use a half cup of SPLENDA® Sugar Blend to replace a full cup of sugar, saving them half the calories and carbohydrates.
SPLENDA® Sugar Blend is great for anyone who wants great-tasting baked goods, but is concerned about the sugar content in traditional recipes. Everyone – including kids – can enjoy the moistness, appearance, and full-sugar taste of baked goods made with SPLENDA® Sugar Blend. SPLENDA® Sugar Blend can also be a great sweetener choice for your patients who want a gradual approach to lowering sugar intake.
Yes. People with diabetes can eat a variety of food products, including foods sweetened with sugar. However, meal plans for people with diabetes usually control total calories and/or carbohydrate intake. When used in place of sugar, SPLENDA® Sugar Blend can help people with diabetes reduce their intake of carbohydrate and calories by providing half the calories and carbohydrate of sugar, but with all of sugar's taste. It is important to note that SPLENDA® Sugar Blend does contain sugar, and that other ingredients in the foods to which it is added may also provide additional calories and carbohydrate. People with diabetes need to count these calories and carbohydrate when planning their meals.
SPLENDA® Sugar Blend is specifically designed for use with baked goods, especially those where sugar has a major role in some of the baked goods' characteristics – like volume, browning, rise, texture, and moistness. SPLENDA® No Calorie Sweetener, Granulated offers more calorie savings and works best in recipes that use sugar for sweetness.
Not necessarily, however sweeteners do more than just provide a sweet taste in many recipes. Some sweeteners also lend color, texture, or flavor and prevent moisture loss. SPLENDA® No Calorie Sweetener, Granulated works best in recipes where sugar mainly plays a sweetening role, such as recipes for fruit fillings, cheesecakes, custards, sauces, and marinades. In these recipes, you can feel comfortable substituting SPLENDA® No Calorie Sweetener, Granulated for other sweeteners.
In some recipes, such as cakes, cookies, and muffins, you may need to make a few changes to the recipe for greater results. Find out more in Cooking and Baking Tips.
Or, you can use SPLENDA® Sugar Blend, which achieves the sweetness, volume, and moistness you expect in your baked goods, but allows you to use half of the sugar you would ordinarily use. When making your favorite recipes, a half-cup of SPLENDA® Sugar Blend replaces a full cup of regular sugar, with a 50% reduction in the sugars and carbohydrate from sugar.
View a short animation on what happens to sucralose after consumption.