Safety Profile

Rigorously Tested, Proven Safe

Recommend Sucralose with Confidence to All of Your Patients

  • Sucralose, the sweetening ingredient in all SPLENDA® Sweetener Products, is one of the most rigorously tested food additives on the market, and has been the subject of more than 110 scientific studies during more than 20 years of research.1

  • Regulatory, health, and food safety authorities worldwide have concluded that sucralose is safe for use by everyone. This means sucralose can be safely used during pregnancy, by people with diabetes, by children, and more.

  • Sucralose is approved for use in more than 80 countries, all without the requirement for any warning label. Sucralose does not cause or promote cancer or pregnancy complications.

  • Sucralose has been used internationally since 1991, with unanimous regulatory agreement that it is a safe sweetener.

Collective Findings of Worldwide Studies on Sucralose

Based on the full body of sucralose safety data, sucralose has been
shown to have:

  • No known side effects
  • No toxicity—no adverse effects seen even in test studies with diets simulating the sweetness of 40+ pounds of sugar per day for life
  • No bioaccumulation
  • No carcinogenicity
  • No genotoxicity
  • No effects on fetal or neonatal development
  • No neurotoxicity
  • No cariogenicity
  • No effect on carbohydrate metabolism (Sucralose is not hydrolyzed or broken down for energy)
  • No calories or carbohydrate
  • No effect on short- or long-term blood glucose control or on insulin secretion

SPLENDA® Brand Sweetener (sucralose) Product MonographPDF

Learn more about the safety of sucralose, the no-calorie sweetening ingredient in all SPLENDA® Sweetener Products, including clinical and pre-clinical safety evaluations and extensive sucralose studies examining tolerance, glycemic control, and use in caloric control.

View product monograph [PDF]

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Answering Patients' Questions about the Safety of SPLENDA® Brand Sweetener (sucralose)

Below, find answers to basic questions patients may have about the safety of SPLENDA® Brand Sweetener (sucralose). Click here to browse more facts and frequently asked questions about SPLENDA® Brand Sweetener (sucralose).

    Sucralose Safety

    Sucralose Tolerability

Watch "Sucralose
in the Body" Video

View a short animation on what happens to sucralose after consumption.


Scientific Studies

Scientific studies support the safety of sucralose. They build on an extensive, rigorous research program that investigated sucralose safety. More than 110 studies, representing over 20 years of research, support the safety of sucralose.

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