SCIENTIFIC STUDIES

Safety Studies

Berry C, Brusick D, Cohen SM, Hardisty JF, Grotz VL, Williams GM: Sucralose non-carcinogenicity: A review of the scientific and regulatory rationale. Nutrition and Cancer: An International Journal.68: published online September 21, 2016 (http://www.tandfonline.com/doi/full/10.1080/01635581.2016.1224366)


This comprehensive safety review of sucralose concludes that sucralose is non-carcinogenic and safe for all consumers to use. This review was published in the journal Nutrition and Cancer and was conducted by experts in pathology, genotoxicity and toxicology, at the request of the makers of SPLENDA® Sweeteners. The review includes both independently conducted and industry-funded research on sucralose chemistry, pharmacokinetics, metabolism, toxicity, genotoxicity, and long-term safety - including carcinogenicity, identified through a comprehensive search of electronic databases. The review clearly lays out the framework used by health and regulatory authorities around the world when they assess the potential carcinogenicity of food ingredients and simultaneously provides a comprehensive review of the many years of sucralose research important to consider when assessing cancer-causing potential.


The collective data in this newly published review support four key points:
   • There is no evidence of chemical concerns or toxicity;
   • No metabolites in sucralose [any breakdown products of the small amount of sucralose that is metabolized] were found to be carcinogenic;
   • No changes to genes were observed to indicate any cancer-causing effects;
   • At doses thousands of times the maximum expected daily intake in humans, toxicity and long-term carcinogenicity studies “showed no evidence of sucralose having carcinogenic potential.”


The findings in this review are consistent with the reviews by the U.S. Food and Drug Administration (FDA), the European Food Safety Authority (EFSA), Health Canada, and many other health and regulatory agencies worldwide all that have approved sucralose as safe for consumption by the entire population.


Berry C, Brusick D, Cohen SM, Hardisty JF, Grotz VL, Williams GM: Sucralose non-carcinogenicity: A review of the scientific and regulatory rationale. Nutrition and Cancer: An International Journal.68: published online September 21, 2016 (http://www.tandfonline.com/doi/full/10.1080/01635581.2016.1224366)


SPLENDA® Brand Sweetener (sucralose) was discovered in 1976, and for the next 20 years was subjected to one of the most extensive and thorough safety testing programs ever conducted on a food additive. The peer-reviewed journal publications below provide a synopsis of the literature. An in-depth review of the research conducted is provided in the publication "An Overview of the Safety of Sucralose."


Sucralose: A Scientific and Safety Review

Grotz VL, Munro IC. An overview of the safety of sucralose. Regul Toxicol Pharmacol 2009;55:1-5.

Grice HC, Goldsmith LA. Sucralose – An overview of the toxicity data. Food Chem Toxicol. 2000;38 Suppl 2:S1-6.

FDA 21CFR101.80.


* Links to third-party websites are provided solely for convenience. Heartland Food Products Group, LLC is not responsible for the content of such websites, and users are solely responsible for compliance with any terms of use thereon.

Know The Facts

Read answers to commonly asked questions about SPLENDA® Sweetener Products, usage, effect of sucralose on blood glucose levels, and comparison with other sweeteners.

splenda-faq
view FAQs

Uncover The Latest

Randomized clinical trials, a meta-analysis and scientific statements further confirm the safety and efficacious use of nonnutritive sweeteners as part of a healthy eating plan for weight loss and maintenance.

VIEW LATEST HANDOUT
Questions or comments? Call toll-free 1-866-867-7536 or Click Here for Customer Service.
© Heartland Consumer Products 1996-2015 | Carmel, Indiana USA. All rights reserved.
This site is published by Heartland Food Products Group, LLC which is solely responsible for its contents. This site and its contents are intended for U.S. healthcare professionals only.
This site may contain links to which our Privacy Policy does not apply. We encourage you to read the Privacy Policy of every website you visit.
Legal Notice  |  Privacy Policy



We have made updates to our site. Please confirm that your current information is correct and enter your medical license number, type, and specialty before continuing so that we can better meet your needs.