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Over 100 studies have demonstrated the safety of sucralose for all people. The below comprehensive review provides an in-depth look at the well-documented evidence of sucralose’s safety and non-carcinogenicity.

Sucralose: A Comprehensive Safety Review

Berry C, Brusick D, Cohen SM, Hardisty JF, Grotz VL, Williams GM: Sucralose non-carcinogenicity: A review of the scientific and regulatory rationale. Nutrition and Cancer: An International Journal.68: published online September 21, 2016

This comprehensive safety review of sucralose concludes that sucralose is non-carcinogenic and safe for all consumers to use. This review was published in the journal Nutrition and Cancer and was conducted by experts in pathology, genotoxicity and toxicology, at the request of the makers of SPLENDA® Sweeteners. The review includes both independently conducted and industry-funded research on sucralose chemistry, pharmacokinetics, metabolism, toxicity, genotoxicity, and long-term safety - including carcinogenicity, identified through a comprehensive search of electronic databases. The review clearly lays out the framework used by health and regulatory authorities around the world when they assess the potential carcinogenicity of food ingredients and simultaneously provides a comprehensive review of the many years of sucralose research important to consider when assessing cancer-causing potential.

The collective data in this newly published review support four key points:

  • There is no evidence of chemical concerns or toxicity;
  • No metabolites in sucralose [any breakdown products of the small amount of sucralose that is metabolized] were found to be carcinogenic;
  • No changes to genes were observed to indicate any cancer-causing effects;
  • At doses thousands of times the maximum expected daily intake in humans, toxicity and long-term carcinogenicity studies “showed no evidence of sucralose having carcinogenic potential.”

The findings in this review are consistent with the reviews by the U.S. Food and Drug Administration (FDA), the European Food Safety Authority (EFSA), Health Canada, and many other health and regulatory agencies worldwide all that have approved sucralose as safe for consumption by the entire population.

SPLENDA® Brand Sweetener (sucralose) was discovered in 1976, and for the next 20 years was subjected to one of the most extensive and thorough safety testing programs ever conducted on a food additive. The peer-reviewed journal publications below provide a synopsis of the literature. An in-depth review of the research conducted is provided in the publication "An Overview of the Safety of Sucralose."

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Sucralose: A Scientific and Safety Review
Grotz VL, Munro IC. An overview of the safety of sucralose. Regul Toxicol Pharmacol2009;55:1-5. Grice HC, Goldsmith LA. Sucralose – An overview of the toxicity data. Food Chem Toxicol. 2000;38 Suppl 2:S1-6.
FDA 21CFR101.80.

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